ea0007p38 | Diabetes, metabolism and cardiovascular | BES2004
Persaud S
, Taylor P
, Poston L
, Asare-Anane H
, Burns C
, Jones P
Objective: To investigate pancreatic beta cell morphology and function in rat adult offspring of dams fed a high fat diet in pregnancy.Methods: Female Sprague Dawley rats were fed either a control breeding diet (4% fat) or a high fat diet (20% animal fat) balanced for vitamins and nutrients. Experimental diets were fed for 10 days prior to mating, throughout pregnancy and weaning. Weaned pups were fed standard low fat chow throughout adult life. The time...